smpСкорая медицинская помощьEMERGENCY MEDICAL CARE2072-6716Northwest State Medical University named after II Mechnikov10.24884/2072-6716-2017-18-4-60-65smp-297Research ArticleОБЗОРЫREVIEWSСОВРЕМЕННАЯ ТАКТИКА ЛЕЧЕНИЯ И ПРОФИЛАКТИКИ ВЕНОЗНЫХ ТРОМБОЗОВ И ТРОМБОЭМБОЛИЙ. РОЛЬ НОВЫХ ПЕРОРАЛЬНЫХ АНТИКОАГУЛЯНТОВ. Часть IIA MODERN APPROACH TO THE TREATMENT AND PROPHYLAXIS OF VENOUS THROMBOEMBOLISM. PART IIШальневВ. И.ShalnevV. I.

доктор медицинских наук, профессор кафедры скорой медицинской помощи;

191015,  Санкт-Петербург,  Кирочная  ул.,  д. 41;  тел.  (812)  583–16–04

vshalnev@gmail.comСеверо-Западный государственный медицинский университет им. И. И. Мечникова, Санкт-ПетербургРоссияNorth-Western State Medical University named after I. I. Mechnikov, St. PetersburgRussian Federation2017231120181846065Copyright © Шальнев В.И., 20182018Шальнев В.И.Shalnev V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://smp.spb.ru/jour/article/view/297

В статье обсуждается проблема венозных тромбозов и тромбоэмболий в клинической практике как одна из основных причин инвалидизирующих инсультов и сердечно-сосудистой смертности. Анализируются современные подходы к лечению и профилактике тромбозов и тромбоэмболий в различных клинических ситуациях, приводятся данные последних национальных и международных рекомендаций по этой теме. Излагаются сравнительные результаты применения различных антитромботических средств при лечении венозных тромбоэмболий и результаты наиболее важных рандомизированных клинических исследований в данной области.

The article highlights the burden of the venous thromboembolism (VTE) in clinical practice as one of the most frequent cause of cardiovascular death and disabling embolic stroke worldwide. The author compares the traditional use of VKA antagonists and new class of oral anticoagulants — direct thrombin and factor Xa inhibitors for VTE treatment and prevention. The results of most significant randomized clinical trials in VTE area and latest international guidelines are also discussed.

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The authors declare that there are no conflicts of interest present.