EXPERIENCE WITH THE USE OF RECOMBINANT SUPEROXIDE DISMUTASE IN THE COMPLEX TREATMENT OF PATIENTS WITH POSTHYPOXIC ENCEPHALOPATHY

Objective: to study the effect of recombinant superoxide dismutase, included in the complex intensive care, on the antioxidant properties of the blood of patients with acute posthypoxic encephalopathy syndrome.

Material and methods. The study included 34 patients who were treated in the intensive care unit with a diagnosis of acute posthypoxic encephalopathy. Group 1 (n=21) was represented by patients who underwent standard intensive care. In group 2 (n=13), the treatment was supplemented with recombinant superoxide dismutase, administered intravenously with a drug dispenser at a dose of 12.8 million units within 12 hours. Consciousness was evaluated on a scale of Glasgow com and activation — sedation on a scale of Richmond. Spontaneous and induced biochemoluminescence (BCL) of whole venous blood was determined.

Results: In patients of group 2 the phenomena of posthypoxic encephalopathy stopped faster than in group 1. In group 2, all patients were extubated 24 hours after the start of respiratory support, in group 1–57% of patients were extubated after 24 hours, the rest 48 hours after the start of treatment. By the end of the first day, in patients of group 1, spontaneous and induced venous blood BCL considerably increased, significantly exceeding the control values. In group 2, spontaneous venous blood BCL by the end of the first day of intensive care was, on average, lower than in patients of group 1 by 43, 85%, and induced by 52, 49% (p<0.05). By the end of the second day, spontaneous blood BCL in group 2, on average, was lower than in group 1 by 9.2%, and induced by 77.9% (p<0.05). 

Conclusion. Intravenous continuous infusion of recombinant superoxide dismutase, at a dose of 12.8 million units, included in the complex intensive care for patients with posthypoxic encephalopathy, reduces the free radical activity of whole venous blood. A decrease in the free radical activity of blood correlates with a decrease in the manifestations of acute posthypoxic encephalopathy. 

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