Effect of intravenous lidocaine introduction on neuromuscular conduction
https://doi.org/10.24884/2072-6716-2025-26-1-44-48
Abstract
The use of lidocaine in a regimen of multimodal anesthesia to reduce doses of anesthetics compared to classical anesthesia is a promising direction in modern anesthesiology. The widespread use of local anesthetics in anesthesiological practice has made it possible to identify their significant effect on the neuromuscular profile. However, the available research on combinations of these drugs with muscle relaxants is very contradictory. Objective. To study the effects of preoperative intravenous lidocaine on neuromuscular conduction. Materials and methods. In order to assess the effect of lidocaine on neuromuscular conduction, 60 patients (ASA I–II) were examined, who underwent laparoscopic cholecystectomy for chronic calculous cholecystitis. Two groups were formed: patients using lidocaine at a dose of 2 mg·kg-1 (30 people, the first group), and patients who used saline (30 people, the second group). Neuromuscular conduction was assessed using the acceleromyography method (monitor TOF-Watch SX). Results. The rate of recovery of neuromuscular conduction was within 47 and 48 minutes in groups 1 and 2, respectively (p=0.92). Conclusion. As a result of the study, it was found that lidocaine did not statistically have a significant effect on neuromuscular transmission.
References
1. Soto G., Naranjo González M., Calero F. Intravenous lidocaine infusion // Revista Espanola de Anestesiologia y Reanimacion. 2018. Vol. 65, No. 5. P. 269–274. doi: 10.1016 /j.redar.2018.01.004.
2. Sloan T., Mongan P., Lyda C., Koht A. Lidocaine infusion adjunct to total intravenous anesthesia reduces the total dose of propofol during intraoperative neurophysiological monitoring // Journal of Clinical Monitoring and Computing. 2014. Vol. 28, No. 2. P. 139–147. doi 10.1007/s10877–013–9506-x.
3. Bestaev G. G., Slepushkin V. D. Muscle relaxants: today, tomorrow: monograph. Vladikavkaz, 2019, 125 p. (In Russ.).
4. Bestaev G. G. Slepushkin V. D. On the issue of factors influencing neuromuscular blockade. Bulletin of Intensive Therapy named after A. I. Soltanova, 2018, No. 2, pp. 36–39 (In Russ.).
5. Bestaev G. G., Slepushkin V. D. Factors influencing the duration of action of the non-depolarizing muscle relaxant Esmeron: analysis of a series of observations. Bulletin of the DSMA, 2020, No. 3 (36), pp. 14–17 (In Russ.).
6. Péréon Y., Bernard J. M., Nguyen S., Genet R., Petitfaux F., Guihéneuc P. The effects of desflurane on the nervous system: from spinal cord to muscles // Anesth. Analg. 1999. Vol. 89, No. 2. P. 490–495. doi: 10.1097/00000539.
7. Hans G.A., Defresne A., Ki B., Bonhomme V., Kaba A., Legrain C., Brichant J. F., Hans P. C. Effect of an intravenous infusion of lidocaine on cisatracurium- induced neuromuscular block duration: a randomized- controlled trial // Acta Anaesthesiol. Scand. 2010. Vol. 54, No. 10. P. 1192–1196. doi: 10.1111/j.1399-6576.2010.02304.
8. Weibel S., Jokinen J., Pace N. L., Schnabel A., Hollmann M. W., Hahnenkamp K., Eberhart L. H., Poepping D. M., Afshari A., Kranke P. Efficacy and safety of intravenous lidocaine for postoperative analgesia and recovery after surgery: a systematic review with trial sequential analysis // Br. J. Anaesth. 2016. Vol. 116, No. 6. P. 770–783. doi: 10.1093/bja/aew101.
9. Kim M.H., Kim M. S., Lee J. H., Kim S. T., Lee J. R. Intravenously administered Lidocaine and magnesium during thyroid surgery in female patients for better quality of recovery after anesthesia // Anesth. Analg. 2018. Vol. 127, No. 3. P. 635–641. doi: 10.1213/ANE.0000000000002797.
10. Katz R.L., Gissen A. J. Effects of intravenous and intra- arterial procaine and lidocaine on neuromuscular transmission in man // Acta Anaesthesiol. Scand. 1969. Vol. 36, No. 1. P. 103–113. doi: 10.1111/j.1399-6576.1969.tb00482.
11. Cardoso L.S., Martins C. R., Tardelli M. A. Effects of intravenous lidocaine on the pharmacodynamics of rocuronium // Rev. Bras. Anestesiol. 2005. Vol. 55, No. 4. P. 371–380. doi: 10.1590/s0034-70942005000400001.
12. Czarnetzki C., Lysakowski C., Elia N., Tramer M. R. Intravenous lidocaine has no impact on rocuronium- induced neuromuscular block. Randomised study // Acta Anaesthesiol. Scand. 2012. Vol. 56, No. 4. P. 474–481. doi: 10.1111/j.1399-6576.2011.02625.
13. Vivancos G.G., Klamt J. G., Garcia L. V. Effects of 2 mg.kg of intravenous lidocaine on the latency of two different doses of rocuronium and on the hemodynamic response to orotracheal intubation // Rev. Bras. Anestesiol. 2011. Vol. 61, No. 1. P. 1–12. doi: 10.1016/S0034-7094(11)70001-0.
14. Feldman S.A., Crawley B. E. Interaction of diazepam with muscle relaxant drugs // Brit. Med. J. 1970. Vol. 1, No. 2. P. 336–338. doi: 10.1136/bmj.2.5705.
15. Zhou H.H., Jin T. T., Qin B., Turndorf H. Suppression of spinal cord motoneuron excitability correlates with surgical immobility during isoflurane anesthesia // Anesthesiology. 1998. Vol. 88, No. 4. P. 955. doi: 10.1097/00000542-199804000-00015.
16. Matsuo S., Rao D. B., Chaudry I., Foldes F. F. Interaction of muscle relaxants and local anesthetics at the neuromuscular junction // Anesth. Analg. 1978. Vol. 57, No. 5. P. 580–587. doi: 10.1213/00000539-197809000-00014.
17. Toft P., Kirkegaard Nielsen H., Severinsen I., Helbo- Hansen H. S. Effect of epidurally administered bupivacaine on atracurium- induced neuromuscular blockade // Acta Anaesthesiol. Scand. 1990. Vol. 34, No. 8. P. 649–652. doi: 10.1111/j.1399-6576.1990.tb03165.
18. Bryssine B., Maurin C., Soubiroud J. L., Ksarelof M., Roche O. Abstract PR425: Interaction of Intravenous Lidocaine with Neuromuscular Blocking // Anesthesia & Analgesia. 2016. Vol. 123, No. 3. P. 538. doi: 10.1213/01.ane.0000492812.61695.cb.
19. Paula-Garcia W.N., Oliveira-Paula G. H., de Boer H. D., Garcia L. V. Lidocaine combined with magnesium sulfate preserved hemodynamic stability during general anesthesia without prolonging neuromuscular blockade: a randomized, double- blind, controlled trial // BMC Anesthesiology. 2021. Vol. 21, No. 1. P. 91. doi: 10.1186/s12871-021-01311-y.
Review
For citations:
Bestaev G.G. Effect of intravenous lidocaine introduction on neuromuscular conduction. EMERGENCY MEDICAL CARE. 2025;26(1):44-48. (In Russ.) https://doi.org/10.24884/2072-6716-2025-26-1-44-48
Views:
225
Email this article 