THE DIRECT AND REMOTE RESULTS OF URGENT ANTIHYPERTENSIVE THERAPY AT THE PRE-HOSPITAL STAGE
https://doi.org/10.24884/2072-6716-2019-0-3-22-29
Abstract
A comparison of the efficacy and safety of the ACE inhibitor captopril and the centrally acting moxonidine has been carried out. The randomized trial included 45 patients randomly divided into two groups. 24 patients received captopril, 21 patients received moxonidine. All patients received furosemide. From the very beginning of the study, blood pressure an heart rate was monitored during the day. It was shown that the efficacy and safety of the compared drugs in the first 30 minutes did not differ significantly. However, the effect of captopril, even in combination with furosemide, lasted no more than 6–8 hours, and moxonidine with furosemide — 18–24 hours. Cases of excessive decrease in blood pressure in both groups were rarely observed. Thus, the compared drugs in the first 30 minutes after administration do not differ in effectiveness. At the same time, daily monitoring of blood pressure showed that the effect of captopril more briefly. Moxonidine acts longer and allows you to more effectively control blood pressure fluctuations during the day. High efficacy and good tolerability of both drugs allow recommending them to patients as a means of self-help in case of high blood pressure. The use of daily monitoring of blood pressure allows to make therapy personalized.
About the Authors
V. V. Ruksin
North-Western State Medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
Viktor V. Ruksin
St. Petersburg
О. V. Grishin
City policlinic No 17
Russian Federation
Russian Federation
Oleg V. Grishin
St. Petersburg
References
1. Golikov F. P. Krizy pri gipertonicheskoj bolezni vchera i segodnya. Arterialnaia gipertenziia: nauchno-prakticheskii zhurnal, 2004, Vol. 10, No 3, рр. 23–27 (in Russ.)
2. Komissarenko I. A. Gipertonicheskie krizy u pozhilyh. Vrach, 2004, No 1, рр. 56–62 (in Russ.)
3. Golikov F. P., Lukiynov M. M., Polumiksov V. U. Novye vozmozhnosti lecheniya i profilaktiki gipertonicheskih krizov u bol’nyh s sochetaniem gipertonicheskoj bolezni i ishemicheskoj bolezni serdca. Kerdiovasculiyrnaia terapiia i profilactika, 2004, Vol. 4, No 3, рр. 10–16 (in Russ.)
4. Gaponova N. I., Plavunov N. F., Tereshhenko S. N. et al. Kliniko-statisticheskij analiz arterial’noj gipertenzii, oslozhnennoj gipertonicheskim krizom, v 2005–2009 gg. Kardiologiia, 2011, Vol. 51, No 2, pp. 40– 44 (in Russ.)
5. Ageev F. G., Fomin I. V., Mareev V. U. et al. Rasprostranennost’ arterial’noj gipertenzii v Evropejskoj chasti Rossijskoj Federacii. Dannye issledovaniya EPOHA 2003. Kardiologiia, 2004, Vol. 12, No 11, pp. 50–53 (in Russ.)
6. Ruksin V. V., Grishin O. V., Sokolov Y. V. et al. Osobennosti neotlozhnyh sostoyanij, svyazannyh s povysheniem arterial’nogo davleniya i differencirovannyj podhod k okazaniyu skoroj medicinskoj pomoshchi. Skoraya medicinskaya pomoshh, 2009, Vol. 10, No 2, pp. 11– 21 (in Russ.)
7. Ruksin V. V., Grishin O. V. Varianty neotlozhnoj sublingval’noj antigipertenzivnoj terapii. Skoraya medicinskaya pomoshh, 2015, Vol. 16, No 1, pp. 15–21 (in Russ.)
8. The Task Force for the management of arterial hypertension of the European Society of Hypertension and of the European Society of Cardiology. 2007 Guidelines for the management of arterial hypertension // J. Hypertens. 2007. No 25. P. 1105–1187.
9. Battegay E., Lip G., Bakris G. Hypertensive emergencies and urgencies: Uncontrolled severe hypertension // Hypertension-Principles and Practice. 2005. P. 651–669.
10. A Comparison of the Reproducibility and the Sensitivity to Change of Visual Analogue Scales, Borg Scales, and Likert Scales in Normal Subjects During Submaximal Exercise / Stan Grant, Tom Aitchison, Esther Henderson et. el. // Chest. 1999. Vol. 116. P. 1208–1217.
11. Unkerov V. I., Grigorev S. G., Rezvancev M. V. Matematiko-statisticheskaya obrabotka dannyh medicinskih issledovanij. SPb: VМeda, 2011, 320 р. (in Russ.)
Review
For citations:
Ruksin V.V., Grishin О.V. THE DIRECT AND REMOTE RESULTS OF URGENT ANTIHYPERTENSIVE THERAPY AT THE PRE-HOSPITAL STAGE. EMERGENCY MEDICAL CARE. 2019;20(3):22-29. (In Russ.) https://doi.org/10.24884/2072-6716-2019-0-3-22-29
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