Еxperimental evaluation of the biodegradation of a national hemostatic surgical polysaccharide resorbable agent
https://doi.org/10.24884/2072-6716-2025-26-2-42-49
Abstract
The aim of the study is a comparative experimental evaluation of the biodegradation of the hemostatic surgical polysaccharide resorbable hemostatic agent «Hemospas® Med». Materials and methods. The study was performed on the biomodel of hemorrhage from the rabbit liver wound, using the foreign analog — absorbable hemostatic powder «PerClot®» as the object of comparison. The observation period was 30 days. Results. The findings indicated complete biodegradation and the absence of the irritating, adhesion-inducing agent «Hemospas® Med. Conclusion. The local hemostatic agent «Hemospas® Med» has demonstrated its efficacy in replacing expensive and hard to get foreign analogues in the practice of emergency surgery of abdominal cavity and retroperitoneal organs.
Keywords
Supporting agencies: the study was funded by MDK Medica LLC (Russia) as part of the research initiative that was commissioned by the company.
About the Authors
A. B. Yudin
State Scientific Research Test Institute of the military medicine, Defense Ministry of the Russian Federation
Russian Federation
Russian Federation
Andrey B. Yudin
St. Petersburg
D. A. Zaichikov
State Scientific Research Test Institute of the military medicine, Defense Ministry of the Russian Federation
Russian Federation
Russian Federation
Denis A. Zaichikov
St. Petersburg
T. S. Soloveva
State Scientific Research Test Institute of the military medicine, Defense Ministry of the Russian Federation
Russian Federation
Russian Federation
Tatyana S. Soloveva
St. Petersburg
L. A. Yudin
Military Medical Academy of S. M. Kirovv
Russian Federation
Russian Federation
Leonid A. Yudin
St. Petersburg
References
1. Abdominal injuries: Study guide. St. Petersburg: State Budgetary Institution of St. Petersburg Research Institute of Emergency Care named after I. I. Dzhanelidze, 2023, 104 р. (In Russ.).
2. Gain Yu.M., Aleksandrova O. S., Gapanovich V. N. Modern methods of local hemostasis in damage to parenchymatous abdominal organs. Surgery News, 2009, Vol. 17, No. 4, рр. 160–171 (In Russ.).
3. Tarkova A. R., Chernyavskiy A.M., Morozov S. V. et al. Local hemostatic agent based on oxidized cellulose. The Sib. Scien. Med. J., 2015, Vol. 35, No 2, рр. 11–15 (In Russ.).
4. Nouri S., Sharif M.R., Afzali H. et al. The Advantages and Disadvantages of Methods Used to Control Liver Bleeding: A Review // Trauma Mon. 2015. Vol. 20, No. 4. Р. e28088. doi: 10.5812.
5. Schmitz C., Sodian R. Use of a plant-based polysaccharide hemostat for the treatment of sternal bleeding after median sternotomy // J. Cardiothorac. Surg. 2015. Vol. 10. Р. 59. doi: 10.1186/s13019-015-0263-4.
6. Aktas E., Kaya A.V., Deveci M.A. et al. Polysaccharide hemostatic system reduces blood loss in high-body-massindex patients undergoing simultaneous bilateral total knee arthroplasty // J. Orthop. Sci. 2012. Vol. 17, No. 4. Р. 432–436.
7. Janczak D., Ruciński A., Rucińska Z. et al. Nowoczesne preparaty o miejscowym działaniu hemostatycznym — przełom w chirurgii naczyniowej [Modern topical hemostatic agents — a breakthrough in vascular surgery] // Polim. Med. 2013. Vol. 43, No. 4, рр. 221–225 (In Russ.)].
8. Voskanyan S. E., Karkischenko V. N., Artemiev A.I. et al. «Tachocomb» and «PerClot» application agents in bovine liver resection. Experimental study. Surgical practice, 2014, No. 4, рр. 10–15 (In Russ.).
9. Von Ahnen T., von Ahnen M., Wirth U. et al. Comparison of an intraoperative application of a haemostatic agent (PerClot®) with conventional haemostatic procedure after thyroid resection // Surg. Sci. 2015. No. 6. Р. 239–246.
10. Rao K., Gomati A., Yuen Hao Tong E. et al. Use of PerClot® in head and neck surgery: a Scottish centre experience // Eur. Arch. Otorhinolaryngol. 2021. Vol. 278, No. 6. Р. 1965–1969.
11. Государственный реестр медицинских изделий и организаций (индивидуальных предпринимателей), осуществляющих производство и изготовление медицинских изделий // URL: https://roszdravnadzor.gov.ru/services/misearch (дата обращения 10.01.2025)
12. Murat F. J., Ereth M. H., Dong Y. et al. Evaluation of microporous polysaccharide hemospheres as a novel hemostatic agent in open partial nephrectomy: favorable experimental results in the porcine model // J. Urol. 2004. Vol. 172, No. 3. Р. 1119–1122.
13. Tan S.R., Tope W. D. Effectiveness of microporous polysaccharide hemospheres for achieving hemostasis in mohs micrographic surgery // Dermatol. Surg. 2004. Vol. 30, No. 6. Р. 908–914.
14. Guidelines for conducting preclinical studies of medicinal products. Part one / edited by A. N. Mironov. Moscow: Publishing House Grif i K, 2012, 944 р. (In Russ.).
15. Meredith A., Lord B. et al. BSAVA Manual of Rabbit Medicine. Gloucester: Waterwells Business Park, Quedgeley, 2014. 328 p.
Review
For citations:
Yudin A.B., Zaichikov D.A., Soloveva T.S., Yudin L.A. Еxperimental evaluation of the biodegradation of a national hemostatic surgical polysaccharide resorbable agent. EMERGENCY MEDICAL CARE. 2025;26(2):42-49. (In Russ.) https://doi.org/10.24884/2072-6716-2025-26-2-42-49
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