Experimental comparative evaluation of the efficacy of a new hemostatic surgical polysaccharide resorbable agent

Abstract

The aim of the study is a comparative experimental evaluation of the efficacy of the surgical polysaccharide absorbable hemostatic agent «Hemospas®Med». For this purpose, the hemostatic efficacy of Hemospas®Med and the comparative agent, AgistaAN, was assessed in a standard model of rabbit liver wound bleeding. Materials and methods. The study was performed in an acute experiment on a biomodel of bleeding from a rabbit liver wound. Hemostatic efficacy was evaluated by the time of bleeding stoppage and the volume of blood loss, calculated relative to the animal›s total blood volume (TBV). Results. According to the results of experimental preclinical approval, the efficacy of «Hemospas®Med» hemostatic surgical polysaccharide absorbent, developed within the framework of import substitution, is comparable to a foreign sample of hemostatic agent based on modified starch. Conclusion. The local hemostatic agent «Hemospas®Med» is as effective as its foreign counterpart and can successfully replace it in the practice of emergency surgery as a supplement to the classical methods of surgical hemostasis in abdominal and retroperitoneal surgery.