Lyell’s syndrome: errors in differential diagnosis at the prehospital stage

The purpose of our study was to study the structure of diagnostic errors at the prehospital stage in order to optimize the routing of patients with Lyell’s syndrome.

Materials and methods. A retrospective analysis of the case histories of all the victims admitted to the inpatient department of the GBU «St. Petersburg Scientific Research Institute of Emergency Medicine named after I. I. Dzhanelidze in the period from 2020 to 2024 was performed. 76 patients were delivered with the leading diagnosis of the sending institution, suggesting a history of Lyell›s syndrome. The frequency of diagnostic errors at the pre-nutritional stage of the NSR was 33% (25 patients). The main groups of nosological forms simulating Lyell›s syndrome are the dermatological group of diseases (48%), as well as the pathology of the traumatological profile (20%), infectious surgical pathology (16%), vascular diseases (8%), systemic (4%) and infectious diseases (4%). The analysis of the structure of diagnostic errors at the pre-hospital stage revealed a number of problems in the qualification of primary care physicians, issues of continuity of medical care, interaction between links in the chain of medical care, the solution of which will reduce the frequency of differential diagnostic errors, improve the quality of medical care for this category of patients.

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