ARTICLES
Objective: to study the effect of recombinant superoxide dismutase, included in the complex intensive care, on the antioxidant properties of the blood of patients with acute posthypoxic encephalopathy syndrome.
Material and methods. The study included 34 patients who were treated in the intensive care unit with a diagnosis of acute posthypoxic encephalopathy. Group 1 (n=21) was represented by patients who underwent standard intensive care. In group 2 (n=13), the treatment was supplemented with recombinant superoxide dismutase, administered intravenously with a drug dispenser at a dose of 12.8 million units within 12 hours. Consciousness was evaluated on a scale of Glasgow com and activation — sedation on a scale of Richmond. Spontaneous and induced biochemoluminescence (BCL) of whole venous blood was determined.
Results: In patients of group 2 the phenomena of posthypoxic encephalopathy stopped faster than in group 1. In group 2, all patients were extubated 24 hours after the start of respiratory support, in group 1–57% of patients were extubated after 24 hours, the rest 48 hours after the start of treatment. By the end of the first day, in patients of group 1, spontaneous and induced venous blood BCL considerably increased, significantly exceeding the control values. In group 2, spontaneous venous blood BCL by the end of the first day of intensive care was, on average, lower than in patients of group 1 by 43, 85%, and induced by 52, 49% (p<0.05). By the end of the second day, spontaneous blood BCL in group 2, on average, was lower than in group 1 by 9.2%, and induced by 77.9% (p<0.05).
Conclusion. Intravenous continuous infusion of recombinant superoxide dismutase, at a dose of 12.8 million units, included in the complex intensive care for patients with posthypoxic encephalopathy, reduces the free radical activity of whole venous blood. A decrease in the free radical activity of blood correlates with a decrease in the manifestations of acute posthypoxic encephalopathy.
Relevance. Among the purposes and target indicators of the implemented National projects by the end of 2024 it should be noted increase in the expected duration of healthy life, increase in total coefficient of birth rate up to 1.7 on one woman which achievement is impossible without ensuring female health. The purpose: the analysis of a flow of the patients of an obstetric and gynecologic profile coming to a versatile hospital of emergency medical service (2015–2019).
Methodology. Data of the versatile 800-bed hospital incorporating 60 beds for patients of an obstetric and gynecologic profile served as materials of a research. Statistical and analytical methods of a research are used.
Results. The analysis of the entering stream (36.4 thousand in 5 years) with the diagnosis on the “obstetrics and gynecology” profile (the diagnosis of the direction) showed that most of them — 50.6% (р<0.01) were directed by the medical organizations of emergency medical service, 36.3% — the medical organizations of polyclinic link, 3.2% — the medical organizations of stationary type, and 9.8% — independently asked for medical care. 77.6% of patients arrived from 9:00 till 21:00, including 32.9% — from 9:00 till 12:00; the condition of 94.3% is regarded as satisfactory (р<0.01), only 71.5% of patients came to specialized offices according to a direction profile. The average time of stay of patients in office was about 2 hours (121.2±117.0 min.).
Conclusion. Development of stationary offices of emergency medical service gives the chance of sorting of the arriving patients according to weight of a state and needs in specialized medical and diagnostic actions. The diagnosis only of 71.5% of the arriving patients corresponds to a direction profile. The share of patients (for 50.2%), capable to ask independently for medical care grows. Every fifth patient who is almost arriving in the emergency order receives adequate (necessary and sufficient) the volume of medical care in office of emergency medical service.